Pieter Jelle Visser
15:00-16:15- session: Real-world healthPieter Jelle Visser is clinical epidemiologist at Amsterdam University medical Centers, Maastricht University, and the Karolinska Institutet in Stockholm. His research focusses on the early stages of the disease, before it causes symptoms. The aim is to understand the mechanisms of the disease, to develop better methods for early diagnosis, and ultimately to lay the foundations for effective treatments against the disease. He has led a series of large European collaborations aimed at creating networks for Alzheimer’s research in order to re-use of existing data for research. He also co-leads the Netherlands Consortium of Dementia Cohorts study, which will facilitate the pooling of data from 9 Dutch cohorts on aging and the dementia. A central track in Visser’s research is to use new tools within proteomics to analyse thousands of proteins in the cerebrospinal fluid in Alzheimer patients with and without dementia. Such a broad mapping can help clarify the mechanisms that lead to the aggregation of beta-amyloid, the key feature of the disease. In this way subtypes of Alzheimer disease may be detected, which each need a specific treatment.
Digital biomarkers in Alzheimer’s disease
Alzheimer’s disease is the most common cause of dementia. It is a slowly progressive disorder and brain abnormalities start to develop 20 years before the start of dementia. In Alzheimer’s disease digital biomarkers may be useful to detect early cognitive changes before dementia onset and may help to monitor function during the dementia phase. The aim of the presentation is to give an overview of the course of Alzheimer’s disease based on data from using electronic health registries, cohort data, and remote measurement tools. Next we will present the outline of the RADAR-AD study. This IMI project was set-up to test the utility of remote measurement technologies in Alzheimer’s disease. We will also present preliminary data on digital phenotyping from the related RADAR-CNS project, which was performed in individuals with depression, multiple sclerosis and epilepsy.
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