Netherlands Bioinformatics Conference 2014

Netherlands Bioinformatics Conference 2014

Jelle Goeman

Jelle Goeman3.jpg

CV

Jelle Goeman is professor of biostatistics at Radboud University Medical Center in Nijmegen. He develops statistical methodology for omics data, e.g. methods for gene set testing, prognostic models, and multiple testing. A common theme in his methods is that they allow biological knowledge to be easily and effectively used as part of the analysis.

Abstract

Title: Flexible multiple testing

Classical methods for multiple testing try to avoid false positive conclusions at all cost. Modern methods based on the False Discovery Rate (FDR), popular in omics data analysis, prefer merely to limit the proportion of false positives among the findings. This is a sensible strategy, as it gives sufficient control over the potential flood of unreliable findings, while simultaneously avoiding too many false negative results. What many users do not realize, however, is that these FDR-based methods allow much less flexibility in the way the results of these methods can be used. For example, simple acts of selection among results or aggregation (e.g. from probe level to gene level) may dramatically increase the proportion of false positives. In this talk I explain why this happens, and propose alternative ways of controlling or estimating the proportion of false positives in such a way that the results allow greater flexibility for the user in later post-processing of the results, e.g. using biological knowledge or bioinformatics tools, while retaining statistically guaranteed properties.

event registration
 event registration