20 April 2017

08:30-17:30

Registration

09:30-09:35

Welcome
René van Lier (Director Sanquin Research & member executive board Sanquin)

09:35-09:40

Introduction
Marian van Kraaij (Conference Chair)

09:40-

SESSION I - Iron physiology

09:40-10:30

Iron homeostasis and its relationship to erythropoiesis
and innate immunity

Tomas Ganz
(David Geffen School of Medicine, Los Angeles, USA)

10:30-11:10

Pumping iron: When monocytes come to the rescue
Filip Swirski
(Massachusetts General Hospital, Boston, USA)

11:10-11:30

Break & posters

11:30-12:10

Devil's dance: heme, iron and hemopexin in hemolysis
Sacha Zeerleder
(Academic Medical Centre and Sanquin Research, Amsterdam, The Netherlands)

12:10-12:30

Poster pitches
Moderator: Robin van Bruggen

12:30-13:30

Lunch & posters

13:30-

SESSION II - Anemia of inflammation

13:30-14:10

Anemia on the ICU, how to fight an ancient foe
Lucas van Eijk
(Radboud University Medical Center, Nijmegen, The Netherlands)

14:10-14:25

DARC epitope exposure explains plasmodium vivax tropism
Francesca Aglialoro
(Sanquin Research, dept Hematopoiesis and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands)

14:25-15:05

Interferon gamma and anemia of inflammation
Katherine MacNamara
(Albany Medical Center, Albany, NY, USA)

15:05-15:30

Break & posters

15:30-

SESSION III - Hemoglobinopathies

15:30-16:10

Genetic and epigenetic regulation of hemoglobin switching
Sjaak Philipsen
(Erasmus Medical Center, Rotterdam, The Netherlands)

16:10-16:25

Dynamics of von Willebrand factor reactivity in sickle cell disease
Brenda Luken
(Sanquin Research, dept Immunopathology and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands)

16:25-17:05

Trojan horses in sickle cell disease
Karin Fijnvandraat
(Academic Medical Center and Sanquin Blood bank & Research, Amsterdam, The Netherlands)

17:05-19:00

Drinks & buffet

21 April 2017

08:00-17:30

Registration

08:30-

SESSION IV - Molecular mechanisms of anemia’s

08:30-09:10

Consequences of DMT1 deficiency on erythropoiesis
Monika Horváthová
(Department of Biology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic)

09:10-09:25

The effect of complement inhibition on erythrocyte destruction in AIHA
Inge Baas
(Sanquin Research, dept Immunopathology and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands)

09:25-10:05

Clinical pathological entities and molecular phenotypes in myelodysplastic syndromes
Arjan van de Loosdrecht
(Department of Hematology, VUmc, Amsterdam, The Netherlands)

10:05-10:30

Break & posters

10:30-

Session V - Donors and iron

10:30-11:10

Monitoring Iron Status of Blood Donors​
Alan Mast
(Blood Center of Wisconsin and Medical College of Wisconsin, USA)

11:10-11:25

11% of Finnish blood donor have iron deficiency - sTFR enrolment data from Fin Donor 10 000 study​
Pia Niittymäki
(Finnish Red Cross Blood Service, Finland)

11:25-12:05

Using plasma hepcidin profiles to optimize iron supplemetation schedules: short and long term studies in young women with depleted iron stores
Diego Moretti
(Swiss Federal Institute of Technology, Zurich, Switzerland)

12:05-13:00

Lunch & posters

13:00-

SESSION VI - Rare congenital anemias

13:00-13:40

Microcytic anemias due to genetic disorders of iron metabolism or heme synthesis
Dorine Swinkels
(Radboud University Medical Center, Nijmegen, The Netherlands)

13:40-13:55

Iron overload in hereditary hemolytic anemia
Stephanie van Straaten
(Dept Clinical Chemistry and Hematology, University Medical Center Utrecht, The Netherlands)

13:55-14:35

Molecular and clinical aspects of Diamond Blackfan Anemia, and related bone marrow failure syndromes
Marcin Wlodarski
(Freiburg University, Freiburg, Germany)

14:35-15:00

Poster prize & Break & posters

15:00-

SESSION VII - New treatments of (congenital) anemia and iron overload

15:00-15:40

The mutual regulation of iron and erythropoiesis: implications for treatment of iron loading anemias
Clara Camaschella
(San Raffaele Scientific Institute, Milano, Italy)

15:40-15:55

Fetal hemoglobin expression in adult erythroid cultures is repressed by CD14+ cells
Steven Heshusius
(Sanquin Research, dept Hematopoiesis and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands)

15:55-16:35

From in vitro erythropoiesis to a red cel product
Emile van den Akker
(Sanquin Research, Amsterdam, The Netherlands)

16:35-18:00

Farewell drinks