Registration

Opening - Christian Wolfrum (ICBL President)

Introduction Van Deenen Lecturer - 

Gerrit van Meer (Utrecht, NL)

The Laurens Van Deenen Lecture 2021

Carsten Schultz (Portland, USA) – Chemical tools for lipid biology

Welcome reception

Arrival with coffee

Membrane Remodeling:

8.30-9.10 Joseph Lorent (Utrecht, NL) - The molecular, structural, and functional asymmetry of the plasma membrane

9.10-9.50 Patricia Bassereau (Paris, France) - Shaping membranes with proteins and consequences on lipid sorting

9.50-10.20 Coffee break + Poster viewing (group A, even numbers) 

10.20-10.50 Short talk: Juliette Vanderroost (Brussels, Belgium) - Membrane cholesterol contributes to myoblast migration and fusion 

10.50-11.20 Short talk: Toon de Kroon (Utrecht, NL) - Shortening of average acyl chain length renders phosphatidylcholine redundant 

Technology I:

11.20-12.00 Claudia Steinem (Gottingen, Germany) - Pore-spanning membranes and their applications to address biological questions

12.00-12.30 Karl Hostetler (UCSD, USA) - Phospholipid Prodrugs of Remdesivir for Oral Treatment of SARS-CoV

LUNCH + Poster Session

(group A, even numbers; with presenters at poster)

Lipid metabolism II:

14.00-14.40 Mario van der Stelt (Leiden, NL) - Chemical proteomics guides the discovery of selective lipid metabolism inhibitors

14.40-15.20 Fred Vaz (Amsterdam, NL) - Lipidomics for inborn errors of metabolism

15.20-15.50 Short talk: Katrin Watschinger (Innsbruck, Austria) - Alkylglycerol monooxygenase is upregulated during adipogenesis in 3T3-L1 and impacts on molecular features of neutral lipids

15.50-16.20 Short talk: Johannes Plagge (Freising, Germany) - The gut microbiota inhibits intestinal lipid absorption

Coffee Break + Poster Viewing

(group A, even numbers)

Technology 2:

17.20-18.00 Christian Eggeling (Jena, Germany / Oxford, UK) - Novel insights into lipid plasma membrane organization with advanced (super-resolution) microscopy

18.00-18.30 Short talk: Gerhard Liebisch (Regensburg, Germany) - Update on Guidelines for Lipidomics Analysis and Reporting

ICBL Steering Committee Meeting  

Arrival with coffee

Lipids & Membranes:

8.30-9.10 Christoph Thiele (Bonn, Germany) - The dynamics of lipid metabolism: Click-MS tracing in hepatocytes and adipocytes

9.10-9.50 Edward Dennis (San Diego, USA) - Allosteric Regulation and Molecular Species Specificity of Phospholipase A2’s in Metabolism

09.50-10.20 Coffee break + Poster viewing (group B, odd numbers) 

10.20-10.50 Short talk: Nicolas Vitale (Strasbourg, France) - Distinct functions of phospholipase D1-derived phosphatidic acid unsaturated species during regulated exocytosis in neuroendocrine cells

10.50-11.20 Short talk: Sarah Brunner (Freising, Germany) - The mitochondrial lipidome of adipose tissue – identification of a browning-specific lipid species signature

Technology 3:

11.20-12.00 Phill Stansfeld (Warwick, UK) - Molecular Simulations of Lipid interactions with Membrane Proteins

12.00-12.30 Short talk: Janathan Michael Juarez Altuzar (Heidelberg, Germany) - Traffic Jam at the lysosome: Novel organelle-targeted lipid probes reveal known cholesterol transporters as sphingosine interactors

LUNCH + Poster Session

(group B, odd numbers; with presenters at poster)

Social program

Hop-on/Hop-off boat tour in Utrecht Center

Conference dinner at Restaurant Djakarta

Arrival with coffee

Lipid-protein interactions:

8.30-9.10 Tim Dafforn (Birmingham, UK) - Extraction and characterization of membrane proteins in their native lipid environment

9.10-9.50 Rachid Thiam (Paris, France) - The power of in vitro reconstitutions for lipid droplet biology

9.50-10.20 Coffee break + Poster viewing (group B, odd numbers) 

10.20-10.50 Short talk: Amaury Stommen (Louvain-la-Neuve, Belgium) - Regulation of PIEZO1 cation channel distribution and gating at the red blood cell surface

10.50-11.20 Short talk: Mike Renne (Oxford, UK) - Seipin promotes packaging of triacylglycerol and steryl esters into Lipid Droplets

Technology 4:

11.20-11.50 Gabor Balogh (Szeged, Hungary) - Development of a laser dissection-coupled quantitative microlipidomic method to resolve tumor heterogeneity

11.50-12.30 Arnold Driessen (Groningen, Netherlands) - Building an in vitro phospholipid biosynthesis pathway

LUNCH + SCIEX seminar

13:00-13:30 Gina L. Eagle (Macclesfield, UK) Using EIEIO as a novel fragmentation technique for complete lipid characterization in a complex matrix

Lipids and Disease:

13.45-14.25 Patrick Rensen (Leiden, NL) - Towards non-invasive lipid-based tracing of brown fat activity 

14.25-15.05 Michael Schlame (New York, USA) - A simple mechanistic model of Barth syndrome and cardiolipin remodelling    

15.05-15.35 Maria Soledad Hidrobo Unda (München, Germany) - Membrane phospholipids as alternative source for free fatty acids fueling UCP1 activity in brown adipocytes 

15.35-16.05 Albert Maimó-Barceló (Palma, Spain) - Exploring the transcriptomic regulation of MALDI-IMS membrane lipid distribution in human colonocyte differentiation and colon cancer 

Coffee Break

Presentation of the 62nd ICBL conference

- Young Investigator award for best poster presentation

- Closing of the conference

Departure