Jeroen Raes
Prof. Jeroen Raes (m) is full professor at
KU Leuven since 2013 and VIB Group
leader since 2009. VIB: Vlaams Instituut voor Biotechnologie.
Picture: ©VIB-IneDehandschutter
Quantitative microbiome profiling in health and disease
Alterations in the gut microbiota have been linked to various pathologies, ranging from inflammatory bowel disease and diabetes to cancer. Although large numbers of clinical studies aiming at microbiome-based disease markers are currently being performed, our basic knowledge about the normal variability of the human intestinal microbiota and its determining factors remains limited. Here, I will discuss our findings studying a large-scale study (Flemish Gut Flora Project; n=3400) of the gut microbiome variation in a geographically confined region (Flanders, Belgium), in which analysis of microbiome variability in health identified the primary parameters associated to microbiome composition. In this presentation, I will discuss our experiences in large-scale microbiome monitoring, show how the development of dedicated computational approaches can assist in microbiome analysis and interpretation, and which confounders are essential for inclusion in microbiome disease research. In addition I will show how Quantitative Microbiome Profiling (QMP; Vandeputte et al. Nature 2017), which combines microbiomics with flow cytometry-based cell counts, is profoundly changing our view on gut microbiota variation and allowed the identification of an inflammation-associated, cross-disease enterotype.
Bio
Prof. Jeroen Raes (m) is full professor at KU Leuven since 2013 and VIB group leader since 2009. His group currently consists of 30 scientists, with expertise in bioinformatics, systems biology, clinical research and microbiology. He has a substantial track record in microbiome research and has been pioneering the analysis and integration of meta-omics datasets (metagenomics, metatranscriptomics, metaproteomics, meta-metabolomics) with environmental, clinical, host omics and dietary data. He was involved in the FP7 MetaHIT and NIH Human Microbiome Project (the latter as only European partner), which laid the foundations for the human microbiome field as it is today. Finally, his lab is performing a wide range of disease-related projects in a.o. IBD, diabetes, cancer, IBS and depression and develops novel approaches and tools for microbiome research. Jeroen Raes coordinates the Flemish Gut Flora project, a large-scale microbiome- focused population cohort in Belgium. He has received multiple awards and recognitions, among which a selection as FWO Odysseus Fellow, a Francqui Chair and selection for Cell journal’s “40 under 40” promising young scientists. His 2011 paper in Nature was selected by Science as part of their “Top 10 breakthroughs of the year 2011”.
Jeroen Raes has published >170 papers in top ranking journals such as Science (8), Nature (15), Nature Biotechnology (4), Nature Microbiology (6), Nature Reviews Microbiology (2), Gut (11) and PNAS (4). He has an h-factor of 69 and his work has been cited >37.000 (ISI).
Metabolomics & the Microbiome Meeting 2022
Registration website for Metabolomics & the Microbiome Meeting 2022Netherlands Metabolomics Centrefemke.francissen@metabolomicscentre.nl
Netherlands Metabolomics Centrefemke.francissen@metabolomicscentre.nlhttps://www.aanmelder.nl/microbiome
2022-09-22
2022-09-22
OfflineEventAttendanceMode
EventScheduled
Metabolomics & the Microbiome Meeting 2022Metabolomics & the Microbiome Meeting 20220.00EUROnlineOnly2019-01-01T00:00:00Z
DSMDSMAlexander Fleminglaan 1 2613 AX Delft Delft Netherlands