Abstract

 

Human iPSC technology to unravel neurodevelopmental disorders with a focus on glial contributions

Human induced pluripotent stem cell (hiPSC) technology presents a groundbreaking avenue for investigating disease- and patient-specific mechanisms. Our research centers on neurodevelopmental and neuropsychiatric disorders, specifically emphasizing the integral role of glial cells in these conditions. By targeting Autism spectrum disorders, GRINopathies, Schizophrenia, 16p11.2 deletions, and white matter disorders, our objective is to elucidate the intricate pathophysiology of these disorders.
In our pursuit of developing targeted therapeutic interventions, close collaboration with clinical experts is pivotal. We validate in vitro models by aligning preclinical findings in hiPSC models with phenotypic observations in clinical settings. During this presentation, I will discuss the innovative use of diverse 2D and 3D hiPSC-based disease models. These models, coupled with advanced imaging, electrophysiological, and OMICs analyses, enable the exploration of dysfunctions in neuron-glia interactions within brain networks.